PAINEL DE CÂNCER HEREDITÁRIO EXPANDIDO - 264 GENES

As síndromes de câncer hereditário são responsáveis por 5 a 10% de todos os diagnósticos para o câncer. A presença de uma variante patogênica em determinados genes leva a um aumento do risco para o desenvolvimento de vários tipos de câncer.


Este exame faz a análise criteriosa em busca de variantes genéticas patogênicas. Variantes benignas não serão reportadas. O Teste inclui análise de Variações no número de cópias (CNV) por NGS.

GENES ANALISADOS
ACD, AIP, AKT1, ALK, ANKRD26, APC, ARMC5, ASCL1, ASXL1, ATM, ATP4A, ATR, AXIN2, BAP1, BARD1, BDNF, BLM, BMPR1A, BPGM, BRAF, BRCA1, BRCA2 ,BRIP1, BUB1B, CABLES1, CASP10, CASP9, CBL, CD70, CDC73, CDH1, CDH23, CDK12, CDK4, CDKN1B, CDKN1C, CDKN2A, CEBPA, CEP57, CHEK1, CHEK2, CREBBP, CSF3R, CTC1, CTNNA1, CTNNB1, CTR9, CYLD, DDB2, DDX41, DICER1, DIS3L2, DKC1, DLST, DNAJC21, DNMT3B, DOCK8, EDN3, EFL1, EGFR, EGLN1, EGLN2, EPAS1, EPCAM, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L2, ETV6, EXT1, EXT2, EZH2, FAN1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FASLG, FBXW7, FGFR1, FH, FIBP, FLCN, FOXE1, G6PC1, GALNT12, GATA1, GATA2, GLMN, GNAS, GPC3, HCLS1, HIF3A, HNF1A, HNF1B, HOXB13, HRAS, IPMK, JAG1, JAK2, KDM1A, KDM3B, KIF1B, KIT, KLLN, KRAS, LAPTM5, LDAH, LIG4, LZTR1, MAD2L2, MAGT1, MAP2K1, MAP2K2, MAP3K1, MAX, MBD4, MCM4 ,MDH2, MEN1, MET, MITF, MLH1, MLH3, MMP1, MNX1, MRE11, MSH2, MSH3, MSH6, MSR1, MTAP, MUTYH, MYCN, NBN, NF1, NF2, NHP2, NME1, NOP10, NRAS, NSD1, NTHL1, NTRK1, NYNRIN, OS9, PALB2, PARN, PAX5, PBRM1, PDGFB, PDGFRA, PDGFRB, PHOX2B, PIK3CA, PMS2, POLD1, POLE, POLH, POT1, PPP2R2A, PPP2R3B, PRF1, PRKAR1A, PSMC3IP, PTCH1, PTCH2, PTEN, PTPN11, RABL3, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RASA2, RASAL1, RB1, RBBP6, RECQL, RECQL4, RET, RFWD3, RHBDF2, RMI2, RNASEL, RNF139, RNF43, RPS20, RRAS, RSPO1, RTEL1, RUNX1, SAMD9, SAMD9L, SASH1, SBDS, SDHA, SDHAF2, SDHB, SDHC, SDHD, SEC23B, SETBP1, SH2B3, SH2D1A, SHOC2 ,SLC25A11, SLX4, SMAD4, SMARCA4, SMARCAD1, SMARCB1, SMARCE1, SOS1, SPRTN ,SRP54, SRP72, STAT3, STK11, SUFU, TERC, TERF2IP, TERT, TET2, TEX15, TGFBR2, THSD1, TINF2, TMC6, TMC8, TMEM127, TOP3A, TP53, TPCN2, TRIM28 ,TRIP13, TSC1, TSC2, UBE2T, USP8, VHL, WAS, WIPF1, WRAP53, WRN, WT1, WWOX, XIAP, XPA, XPC, XRCC2 e ZNF687.